高锦豪

高锦豪/Jinhao Gao
教授、博士生导师
电话：86-592-2180278
传真：86-592-2189959
办公室：卢嘉锡楼528室
电子邮箱：jhgao@xmu.edu.cn
课题组网站： https://jhgao.xmu.edu.cn/

个人简历：

学士（南京大学 2004）
博士（香港科技大学 2008）
博士后（斯坦福大学 2010）
教授（厦门大学 2010.6-）

获奖情况：

香港青年科学家奖 (2007) ，教育部“新世纪优秀人才支持计划”（2010），福建省“闽江学者”特聘教授（2011），福建省杰出青年科学基金（2012），国家优秀青年科学基金（2012），中国化学会青年化学奖（2014），福建省青年拔尖创新人才（2014），霍英东教育基金会青年教师奖（2016），国家杰出青年科学基金（2021）

研究兴趣：
影像化学生物学；磁共振造影剂；¹⁹F磁共振探针；金属化学生物学；肿瘤诊疗；分子探针

近期主要代表论著： 

1. (1). Luo, X.; Gong, X.; Su, L.; Lin, H.; Yang, Z.; Yan, X.; Gao, J. H.* Activatable Mitochondria-Targeting Organoarsenic Prodrugs for Bioenergetic Cancer Therapy. Angew. Chem. Int. Ed. 2021, 60, 1403-1410.

2. (2). Lin, H. Y.; Tang, X.; Li, A.; Gao, J. H.* Activatable ¹⁹F MRI Nanoprobes for Visualization of Biological Targets in Living Subjects. Adv. Mater. 2021, 33, 2005657.

3. (3). Zhu, X. L.; Tang, X.; Lin, H. Y.; Shi, S.; Xiong, H.; Zhou, Q.; Li, A.; Wang, Q.; Chen, X.; Gao, J. H.* A Fluorinated Ionic Liquid-Based Activatable ¹⁹F MRI Platform Detects Biological Targets. Chem 2020, 6, 1134-1148.

4. (4). Sun, C. J.; Lin, H. Y.; Gong, X. Q.; Yang, Z.; Mo, Y.; Chen, X.; Gao, J. H.* DOTA-Branched Organic Frameworks as Giant and Potent Metal Chelators. J. Am. Chem. Soc. 2020, 142, 198-206.

5. (5). Ruan, C.; Wang, C.; Gong, X.; Zhang, Y.; Deng, W.; Zhou, J.; Huang, D.; Wang, Z.; Zhang, Q.; Guo, A.; Lu, J.; Gao, J. H.*; Peng, D.*; Xue, Y.* An Integrative Multi-Omics Approach Uncovers the Regulatory Role of CDK7 and CDK4 in Autophagy Activation Induced by Silica Nanoparticles. Autophagy 2021, 17, 1426-1447.

6. (6). Shi, C.; Zhou, Z.*; Lin, H.*; Gao, J. H.* Imaging Beyond Seeing: Early Prognosis of Cancer Treatment. Small Methods 2021, 5, 2001025.

7. (7). Tang, X.; Gong, X. Q.; Li, A.; Lin, H. Y.; Peng, C.; Zhang, X.; Chen, X.; Gao, J. H.* Cascaded Multiresponsive Self-Assembled ¹⁹F MRI Nanoprobes with Redox-Triggered Activation and NIR-Induced Amplification. Nano Lett. 2020, 20, 363-371.

8. (8). Zhou, Z.; Yang, L.; Gao, J. H.*; Chen, X.* Structure–Relaxivity Relationships of Magnetic Nanoparticles for Magnetic Resonance Imaging. Adv. Mater. 2019, 31, 1804567.

9. (9). Zhang, Y. J.*; Zhang, L.; Gao, J. H.*; Wen, L. P.* Pro-Death or Pro-Survival: Contrasting Paradigms on Nanomaterial-Induced Autophagy and Exploitations for Cancer Therapy. Acc. Chem. Res. 2019, 52, 3164-3176.

10. (10). Wei, R.; Gong, X.; Lin, H.; Zhang, K.; Li, A.; Liu, K.; Shan, H.; Chen, X.; Gao, J. H.* Versatile Octapod-Shaped Hollow Porous Manganese(II) Oxide Nanoplatform for Real-Time Visualization of Cargo Delivery. Nano Lett. 2019, 19, 5394-5402.

11. (11). Tang, X.; Gong, X. Q.; Ming, J.; Chen, D. X.; Lin, H. Y.*; Gao, J. H.* Fluorinated Gadolinium Chelate-Grafted Nanoconjugates for Contrast-Enhanced T₁-Weighted ¹H and pH-Activatable ¹⁹F Dual-Modal MRI. Anal. Chem. 2020, 92, 16293-16300.

12. (12). Li, A.; Tang, X.; Gong, X.; Chen, H.; Lin, H. Y.*; Gao, J. H.* A Fluorinated Bihydrazide Conjugate for Activatable Sensing and Imaging of Hypochlorous Acid by ¹⁹F NMR/MRI. Chem. Commun. 2019, 55, 12455-12458.

13. (13). Yang, L.; Wang, Z.; Ma, L.; Li, A.; Xin, J.; Wei, R.; Lin, H.; Wang, R.; Chen, Z.; Gao, J. H.* The Roles of Morphology on the Relaxation Rates of Magnetic Nanoparticles. ACS Nano 2018, 12, 4605-4614.

14. (14). , L. R.; Lin, H. Y.; Chi, X. Q.; Sun, C. J.; Huang, J. Q.; Tang, X. X.; Chen, H. M.; Luo, X. J.; Yin, Z. Y.; Gao, J. H.* A Self-Assembled Biocompatible Nanoplatform for Multimodal MR/Fluorescence Imaging Assisted Photothermal Therapy and Prognosis Analysis. Small 2018, 14, 1801612.

15. (15). Zhou, Z.; Wu, C.; Liu, H.; Zhu, X.; Zhao, Z.; Wang, L.; Xu, Y.; Ai, H.; Gao, J. H.* Surface and Interfacial Engineering of Iron Oxide Nanoplates for Highly Efficient Magnetic Resonance Angiography. ACS Nano 2015, 9, 3012-3022.

16. (16). Zhao, Z.; Wang, X.; Zhang, Z.; Zhang, H.; Liu, H.; Zhu, X.; Li, H.; Chi, X.; Yin, Z.; Gao, J. H.* Real-Time Monitoring of Arsenic Trioxide Release and Delivery by Activatable T₁ Imaging. ACS Nano 2015, 9, 2749-2759.

17. (17). Zhou, Z.; Zhao, Z.; Zhang, H.; Wang, Z.; Chen, X.; Wang, R.; Chen, Z.; Gao, J. H.* Interplay between Longitudinal and Transverse Contrasts in Fe₃O₄ Nanoplates with (111) Exposed Surfaces. ACS Nano 2014, 8, 7976-7985.

18. (18). Zhao, Z. H.; Zhou, Z. J.; Bao, J. F.; Wang, Z. Y.; Hu, J.; Chi, X. Q.; Ni, K. Y.; Wang, R. F.; Chen, X. Y.; Chen, Z.; Gao, J. H.* Octapod Iron Oxide Nanoparticles as High-Performance T₂ Contrast Agents for Magnetic Resonance Imaging. Nat. Commun. 2013, 4, 2266.

19. (19). Zhou, Z. J.; Wang, L. R.; Chi, X. Q.; Bao, J. F.; Yang, L. J.; Zhao, W. X.; Chen, Z.; Wang, X. M.; Chen, X. Y.; Gao, J. H.* Engineered Iron-Oxide-Based Nanoparticles as Enhanced T₁ Contrast Agents for Efficient Tumor Imaging. ACS Nano 2013, 7, 3287-3296.

20. (20). Zhou, Z. J.; Huang, D. T.; Bao, J. F.; Chen, Q. L.; Liu, G.; Chen, Z.; Chen, X. Y.; Gao, J. H.* A Synergistically Enhanced T₁-T₂ Dual-Modal Contrast Agent. Adv. Mater. 2012, 24, 6223-6228.